The Effect of Actinoquinol with Hyaluronic Acid in Eye Drops on the Optical Properties and Oxidative Damage of the Rabbit Cornea Irradiated with UVB Rays

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A8102" target="_blank" >RIV/00216208:11110/10:8102 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/10:00349269 RIV/61389013:_____/10:00349269

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Effect of Actinoquinol with Hyaluronic Acid in Eye Drops on the Optical Properties and Oxidative Damage of the Rabbit Cornea Irradiated with UVB Rays

Original language description

Irradiation of the cornea with UVB rays leads to its oxidative damage, swelling and loss of transparency. We investigated changes in the corneal hydration, light absorption and microscopical disturbances of corneas irradiated with UVB rays as influencedby eye drops containing actinoquinol with hyaluronic acid. Rabbit corneas were irradiated with two doses of UVB rays (312 nm) for 4 days. During irradiation, the eye drops were applied on the right eye and buffered saline (or hyaluronic acid) on the lefteye. On day 5 the rabbits were sacrificed and the corneas examined spectrophotometrically for light absorption. The corneal thickness (hydration) was measured using a pachymeter. Corneas of some other rabbits were examined immunohistochemically. UVB rays evoked changes in the corneal optics and induced oxidative damage of the corneas. After actinoquinol-hyaluronic acid application, these changes were diminished. Hyaluronic acid alone was less effective.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Photochemistry and Photobiology

ISSN

0031-8655

e-ISSN

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Volume of the periodical

86

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

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UT code for WoS article

000284429500019

EID of the result in the Scopus database

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