Cortisol kinetics in cerebrospinal fluid during bacterial meningitis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10959" target="_blank" >RIV/00216208:11110/11:10959 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/11:00003171 RIV/00064211:_____/11:#0000160
Result on the web
<a href="http://dx.doi.org/10.1016/j.jocn.2010.12.020" target="_blank" >http://dx.doi.org/10.1016/j.jocn.2010.12.020</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cortisol kinetics in cerebrospinal fluid during bacterial meningitis
Original language description
Bacterial meningitis (BM) remains an infectious disease with a significant morbidity and mortality. The aim of this study was to describe the kinetics of cerebrospinal fluid (CSF) cortisol levels during BM and to assess its relationship to disease severity and etiology. A total of 55 patients with BM were enrolled in the study. Elevated CSF cortisol upon admission and its rapid decrease after starting therapy were associated with increased BM severity as assessed by the Acute Physiology and Chronic Health Evaluation II score, the Sequential Organ Failure Assessment score, Glasgow Coma Scale score and the Glasgow Outcome Scale score. The comparison of CSF cortisol according to BM etiology revealed a trend toward higher concentrations in meningitis caused by Streptococcus pneumoniae compared to Neisseria meningitidis. Our results demonstrate that the initially elevated CSF cortisol concentrations decrease rapidly after administration of BM therapy (i.e. antibiotics and dexamethasone). Mo
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Project
<a href="/en/project/NT11390" target="_blank" >NT11390: New biomarkers for a rapid detection of nosocomial infection in intensive care</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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