Selected Biomarkers Correlate with the Origin and Severity of Sepsis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F18%3A00000410" target="_blank" >RIV/61383082:_____/18:00000410 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/18:10376673 RIV/00216208:11120/18:43916652 RIV/00843989:_____/18:E0107096 RIV/00064211:_____/18:W0000138
Result on the web
<a href="https://www.hindawi.com/journals/mi/2018/7028267/" target="_blank" >https://www.hindawi.com/journals/mi/2018/7028267/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2018/7028267" target="_blank" >10.1155/2018/7028267</a>
Alternative languages
Result language
angličtina
Original language name
Selected Biomarkers Correlate with the Origin and Severity of Sepsis
Original language description
The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction. © 2018 Michal Holub et al.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MEDIATORS OF INFLAMMATION
ISSN
0962-9351
e-ISSN
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Volume of the periodical
2018
Issue of the periodical within the volume
Article Number: 7028267
Country of publishing house
GB - UNITED KINGDOM
Number of pages
1
Pages from-to
"nestránkováno"
UT code for WoS article
000429725200001
EID of the result in the Scopus database
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