Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8838" target="_blank" >RIV/00216208:11110/11:8838 - isvavai.cz</a>

Alternative codes found

RIV/00064211:_____/11:#0000086

Result on the web

<a href="http://dx.doi.org/10.1007/s15010-011-0126-4" target="_blank" >http://dx.doi.org/10.1007/s15010-011-0126-4</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

Original language description

The goal of this study was to evaluace routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. In this prospective study, 54 adult patients with bacterial infections were included. For comparison, 27 patients with viral infections were enrolled. In these patients, white blood cell (WBC) counts, differential blood counts, serum levels of procalcitonin (PCT), IL-1b, IL-6, IL-8, IL-10, IL-12, TNF-a, IFN-c, soluble CD14 (sCD14), heparinbinding protein (HBP), cortisol (Cort), and monocyte surface expression of TLR2, TLR4, HLA-DR, and CD14 were analyzed. The highest sensitivity and specificity (expressed as the area under the curve [AUC]) for bacterial infection were observed in serum concentration of PCT (0.952), neutrophil and lymphocyte counts (0.852 and 0.841, respectively), and serumlevels of HBP (0.837), IL-6 (0.830), and Cort (0.817). From the novel potential biomarkers, only PCT demonstrated superiority over the routine parameters in the dif

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/NT11390" target="_blank" >NT11390: New biomarkers for a rapid detection of nosocomial infection in intensive care</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Infection

ISSN

0300-8126

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

411-417

UT code for WoS article

000296843100004

EID of the result in the Scopus database

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