Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8781" target="_blank" >RIV/00216208:11110/11:8781 - isvavai.cz</a>
Alternative codes found
RIV/00064211:_____/11:#0000165
Result on the web
<a href="http://dx.doi.org/10.2174/157016211795569078" target="_blank" >http://dx.doi.org/10.2174/157016211795569078</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation
Original language description
The objectives of our study were to analyse the frequency and functional status of HIV-specific CD8+ T cells and the expression of non-specific activation markers on CD8+ T cells in HIV+ patients. We examined 28 HIV+ patients, including 13 patients not receiving therapy complex antiretroviral therapy (cART) using ELISpot assay and flow cytometry with intracellular and MHC tetramer staining. The results suggested that the alterations of HIV-specific immunity are not influenced by the therapy of HIV infection; whereas, the non-specific chronic immune activation is down-regulated by cART.
Czech name
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Czech description
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Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Project
<a href="/en/project/GD310%2F05%2FH533" target="_blank" >GD310/05/H533: Study of infectious diseases and their causative agents</a>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP) Z - Vyzkumny zamer (s odkazem do CEZ) S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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