The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296318" target="_blank" >RIV/00216208:11110/15:10296318 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/15:#0000404 RIV/00064211:_____/15:#0000464
Result on the web
<a href="http://dx.doi.org/10.1155/2015/271842" target="_blank" >http://dx.doi.org/10.1155/2015/271842</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/271842" target="_blank" >10.1155/2015/271842</a>
Alternative languages
Result language
angličtina
Original language name
The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients
Original language description
A relationship between latent toxoplasmosis and the immune system during HIV disease is poorly understood. Therefore, the aim of this follow-up study was to characterize immunological parameters in HIV-infected patients with latent toxoplasmosis and noninfected individuals. A total of 101 HIV-infected patients were enrolled in the study. The patients were classified into two groups based on anti-Toxoplasma gondii antibodies: a group of 55 toxoplasma-positive persons (TP) and a group of 46 toxoplasmanegative persons (TN). Absolute counts of several lymphocyte subsets decreased in the TP group, namely, T cells (p = 0.007), B cells (p = 0.002), NK cells (p = 0.009), CD4 T cells (p = 0.028), and CD8 T cells (p = 0.004). On the other hand, the percentage ofCD8 T cells expressing CD38 and HLA-DR significantly increased during the follow-up in the TP group (p = 0.003, p = 0.042, resp.) as well as the intensity of CD38 and HLA-DR expression (MFI) on CD8 T cells (p = 0.001, p = 0.057, resp.).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed Research International
ISSN
2314-6133
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
June
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000358496100001
EID of the result in the Scopus database
2-s2.0-84938153858