The effect of latent Toxoplasma gondii infection on the immune response in HIV-infected patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F15%3A00010889" target="_blank" >RIV/75010330:_____/15:00010889 - isvavai.cz</a>

Result on the web

<a href="http://www.hindawi.com/journals/bmri/2015/271842/" target="_blank" >http://www.hindawi.com/journals/bmri/2015/271842/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2015/271842" target="_blank" >10.1155/2015/271842</a>

Result language

angličtina

Original language name

The effect of latent Toxoplasma gondii infection on the immune response in HIV-infected patients

Original language description

A relationship between latent toxoplasmosis and the immune system during HIV disease is poorly understood. Therefore, the aim of this follow-up study was to characterize immunological parameters in HIV-infected patients with latent toxoplasmosis and noninfected individuals. A total of 101 HIV-infected patients were enrolled in the study. The patients were classified into two groups based on anti-Toxoplasma gondii antibodies: a group of 55 toxoplasma-positive persons (TP) and a group of 46 toxoplasma-negative persons (TN). Absolute counts of several lymphocyte subsets decreased in the TP group, namely, T cells (p=0.007), B cells (p=0.002), NK cells (p=0.009), CD4 T cells (p=0.28), and CD8 T cells (p=0.004). On the other hand, the percentage of CD8 T cells expressing CD38 and HLA-DR significantly increased during the follow-up in the TP group (p=0.003,p=0.042, resp.) as well as the intensity of CD38 and HLA-DR expression (MFI) on CD8 T cells (p=0.001,p=0.057, resp.). In the TN group, analysis of the kinetics of immunological parameters revealed no significant changes over time. In conclusion, the results suggest that latent T. gondii infection modulates the immune response during HIV infection.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/NT11429" target="_blank" >NT11429: Effect of long-term asymptomatic Toxoplasma gondii infection on the immune and clinical state of HIV-positive patients</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BioMed Research International

ISSN

2314-6141

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

Art.no. 271842

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

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UT code for WoS article

000358496100001

EID of the result in the Scopus database

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