Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43908495" target="_blank" >RIV/00216208:11120/15:43908495 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/15:00010438 RIV/00216208:11110/15:10285847
Result on the web
<a href="http://dx.doi.org/10.1017/S0950268814001253" target="_blank" >http://dx.doi.org/10.1017/S0950268814001253</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0950268814001253" target="_blank" >10.1017/S0950268814001253</a>
Alternative languages
Result language
angličtina
Original language name
Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients
Original language description
To determine changes in incidence of reactivation of Toxoplasma gondii infection, manifesting as toxoplasmic encephalitis, and to assess the immunological mechanisms controlling reactivation in HIV- infected patients, a Czech cohort of 502 HIV/T. gondiico-infected patients was followed for 2909 3 person-years. The incidence of toxoplasmic encephalitis between the periods before and after the introduction of combination antiretroviral therapy (cART) was compared. Toxoplasmic encephalitis was diagnosed in 21 patients. In those patients the geometric mean value of CD4+ T lymphocytes was 12 6 times lower than in patients with non-reactivated T. gondii infection but an additionally significant decline in CD8+ T lymphocytes (3 3-fold) and natural killer cells (4 3-fold) was observed. This confirms the significance of these parameters. A twelvefold decrease in Toxoplasma reactivation incidence (40 2 vs. 3 4/1000 person-years) between monitored periods was seen. In the cART era, Toxoplasma re
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11429" target="_blank" >NT11429: Effect of long-term asymptomatic Toxoplasma gondii infection on the immune and clinical state of HIV-positive patients</a><br>
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epidemiology and Infection
ISSN
0950-2688
e-ISSN
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Volume of the periodical
143
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
600-607
UT code for WoS article
000348646700018
EID of the result in the Scopus database
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