Incidence and clinical and immunological characteristics of primary Toxoplasma gondii infection in HIV-infected patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10194853" target="_blank" >RIV/00216208:11110/13:10194853 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/13:43907422 RIV/75010330:_____/13:00010071
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijid.2013.03.017" target="_blank" >http://dx.doi.org/10.1016/j.ijid.2013.03.017</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijid.2013.03.017" target="_blank" >10.1016/j.ijid.2013.03.017</a>

Result language
angličtina
Original language name
Incidence and clinical and immunological characteristics of primary Toxoplasma gondii infection in HIV-infected patients
Original language description
Objectives: To determine the incidence and laboratory characteristics of primary Toxoplasma gondii infection in HIV-infected individuals. Methods: This retrospective study was conducted between 1988 and 2012 on a cohort of 1130 HIV-infected patients at the AIDS Center Prague. Toxoplasma serology, standard laboratory parameters, and health status were evaluated at 3-6-month intervals for all patients. Results: The total person-time of follow-up of patients at risk of Toxoplasma seroconversion was 3046.3years; there were 14 primary T. gondii infections, yielding an incidence rate of 0.0046 (95% confidence interval 0.0027-0.0078). Most of the subjects were clinically asymptomatic, but in one case seroconversion was accompanied by transient cervical lymphadenopathy. The CD4+ T-lymphocyte count geometric mean increased from 418 (95% confidence interval 303-579) cells/ml before seroconversion to 501 (95% confidence interval 363-691) cells/ml after seroconversion (p = 0.004), while other par
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Project
<a href="/en/project/NT11429" target="_blank" >NT11429: Effect of long-term asymptomatic Toxoplasma gondii infection on the immune and clinical state of HIV-positive patients</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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