Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F15%3A%230000412" target="_blank" >RIV/00064211:_____/15:#0000412 - isvavai.cz</a>

Result on the web

<a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9527963&fileId=S0950268814001253" target="_blank" >http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9527963&fileId=S0950268814001253</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0950268814001253" target="_blank" >10.1017/S0950268814001253</a>

Result language

angličtina

Original language name

Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients

Original language description

To determine changes in incidence of reactivation of Toxoplasma gondii infection, manifesting as toxoplasmic encephalitis, and to assess the immunological mechanisms controlling reactivation in HIV-infected patients, a Czech cohort of 502 HIV/T. gondii co-infected patients was followed for 2909 x 3 person-years. The incidence of toxoplasmic encephalitis between the periods before and after the introduction of combination antiretroviral therapy (cART) was compared. Toxoplasmic encephalitis was diagnosedin 21 patients. In those patients the geometric mean value of CD4+ T lymphocytes was 12 x 6 times lower than in patients with non-reactivated T. gondii infection but an additionally significant decline in CD8+ T lymphocytes (3 x 3-fold) and natural killer cells (4 x 3-fold) was observed. This confirms the significance of these parameters. A twelvefold decrease in Toxoplasma reactivation incidence (40 x 2 vs. 3 x 4/1000 person-years) between monitored periods was seen. In the cART era, To

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/NT11429" target="_blank" >NT11429: Effect of long-term asymptomatic Toxoplasma gondii infection on the immune and clinical state of HIV-positive patients</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epidemiology and Infection

ISSN

1469-4409

e-ISSN

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Volume of the periodical

143

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

600-607

UT code for WoS article

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EID of the result in the Scopus database

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