Carbon Nanotubes Activate Store-Operated Calcium Entry in Human Blood Platelets

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9055" target="_blank" >RIV/00216208:11110/11:9055 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/11:00003364 RIV/00023698:_____/11:#0000066
Result on the web
<a href="http://dx.doi.org/10.1021/nn2015369" target="_blank" >http://dx.doi.org/10.1021/nn2015369</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Carbon Nanotubes Activate Store-Operated Calcium Entry in Human Blood Platelets
Original language description
Carbon nanotubes (CNTs) are known to potentiate arterial thrombosis in animal models, which raises serious safety Issues concerning environmental or occupational exposure to CNTs and their use in various biomedical applications. We have shown previouslythat different CNTs, but not fullerene (nC60), induce the aggregation of human blood platelets. To date, however, a mechanism of potentially thrombogenic CNT-induced platelet activation has not been elucidated. Here we show that pristine multiwalled CNTs(MWCNTs) penetrate platelet plasma membrane without any discernible damage but interact with the dense tubular system (DTS) causing depletion of platelet intracellular Ca(2+) stores. This process is accompanied by the clustering of stromal interaction molecule 1 (STIM1) colocalized with Orai1, indicating the activation of store-operated Ca(2+) entry (SOCE). Our findings reveal the molecular mechanism of CNT-induced platelet activation which is critical in the evaluation of the biocompat
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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