The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272441" target="_blank" >RIV/00216208:11110/14:10272441 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.biomaterials.2014.04.067" target="_blank" >http://dx.doi.org/10.1016/j.biomaterials.2014.04.067</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biomaterials.2014.04.067" target="_blank" >10.1016/j.biomaterials.2014.04.067</a>

Result language

angličtina

Original language name

The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets

Original language description

Carbon nanotubes (CNT) are one of the most promising nanomaterials for use in medicine. The blood biocompatibility of CNT is a critical safety issue. In the bloodstream, proteins bind to CNT through non-covalent interactions to form a protein corona, thereby largely defining the biological properties of the CNT. Here, we characterize the interactions of carboxylated-multiwalled carbon nanotubes (CNTCOOH) with common human proteins and investigate the effect of the different protein coronas on the interaction of CNTCOOH with human blood platelets (PLT). Molecular modeling and different photophysical techniques were employed to characterize the binding of albumin (HSA), fibrinogen (FBG), gamma-globulins (IgG) and histone H1 (H1) on CNTCOOH. We found thatthe identity of protein forming the corona greatly affects the outcome of CNTCOOH's interaction with blood PLT. Bare CNTCOOH-induced PLT aggregation and the release of platelet membrane microparticles (PMP). HSA corona attenuated the PLT

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/LH12014" target="_blank" >LH12014: Evaluation of cellular toxicity of nanoparticles and protein amyloid fibrils.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomaterials

ISSN

0142-9612

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

24

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

6182-6194

UT code for WoS article

000338804500005

EID of the result in the Scopus database

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