Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9505" target="_blank" >RIV/00216208:11110/11:9505 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/11:00361620

Result on the web

<a href="http://dx.doi.org/10.1186/1471-230X-11-47" target="_blank" >http://dx.doi.org/10.1186/1471-230X-11-47</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis

Original language description

Oral thiopurines are effective and widely used in treatment of inflammatory bowel disease (IBD) in humans, although their use is limited due the development of adverse events. Here, we examine the efficacy and toxicity of oral treatment with 6-tioguanine(6-TG) and azathioprine (AZA) in a murine model of IBD. In chronic colitis, all thiopurine derivatives improved colitis, 20 mu g of 6-TG per dose was superior. High doses of 6-TG led to significant weight loss at the end of the therapy, but none of thethiopurine derivatives increased levels of serum ALT. Both thiopurine derivatives reduced the proportion of apoptotic T helper cells, but a high production of both IL-6 and TGF-beta was observed only in colon of AZA-treated mice. Use of 6-TG in the treatment of experimental colitis in mice appears superior to AZA

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Gastroenterology

ISSN

1471-230X

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

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Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000290792100001

EID of the result in the Scopus database

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