Heme arginate potentiates latent HIV-1 reactivation while inhibiting the acute infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9525" target="_blank" >RIV/00216208:11110/11:9525 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/11:10131667
Result on the web
<a href="http://dx.doi.org/10.1016/antiviral.2011.09.011" target="_blank" >http://dx.doi.org/10.1016/antiviral.2011.09.011</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Heme arginate potentiates latent HIV-1 reactivation while inhibiting the acute infection
Original language description
Human immunodeficiency virus-1 (HIV-1) successfully escapes from host immune surveillance, vaccines and antiretroviral agents. The available antiretroviral compounds can only control viremia, but it is impossible to eliminate the virus from the organism,namely because HIV-1 provirus persists in the reservoir cells from which the virus repeatedly disseminates into new cells. Current therapeutic approaches, however, do not specifically address the stage of virus reactivation. In this paper, we show thatNormosang (heme arginate; HA) appears to possess a combination of unique properties that could help to decrease the pool of latently infected reservoir cells, while simultaneously inhibiting HIV-1 replication in newly infected cells. The stimulatory effects of HA on HIV-1 reactivation seem to involve HO-1 and generation of free radicals. Our results thus suggest a new direction to explore in treatment of HIV/AIDS disease
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GD310%2F05%2FH533" target="_blank" >GD310/05/H533: Study of infectious diseases and their causative agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Antiviral Research
ISSN
0166-3542
e-ISSN
—
Volume of the periodical
92
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
13
Pages from-to
434-446
UT code for WoS article
000298127100005
EID of the result in the Scopus database
—