The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9999" target="_blank" >RIV/00216208:11110/11:9999 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/11:#0001045

Result on the web

<a href="http://dx.doi.org/10.1136/ard.2010.148296" target="_blank" >http://dx.doi.org/10.1136/ard.2010.148296</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic sclerosis

Original language description

These data demonstrate that JunD is overexpressed in SSc and that JunD is a mediator of the profibrotic effects of TGFbeta. Considering that inhibitors of AP-1 signalling have recently been These data demonstrate that JunD is overexpressed in SSc and that JunD is a mediator of the profibrotic effects of TGFbeta. Considering that inhibitors of AP-1 signalling have recently been developed and are available for clinical trials in SSc, these findings may have translational implications.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annals of Rheumatic Diseases

ISSN

0003-4967

e-ISSN

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Volume of the periodical

70

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

1320-1326

UT code for WoS article

000291028800025

EID of the result in the Scopus database

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