Inhibition of activator protein 1 signaling abrogates transforming growth factor beta-mediated activation of fibroblasts and prevents experimental fibrosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12676" target="_blank" >RIV/00216208:11110/12:12676 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/art.33501/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/art.33501/abstract</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Inhibition of activator protein 1 signaling abrogates transforming growth factor beta-mediated activation of fibroblasts and prevents experimental fibrosis

Original language description

We demonstrate that AP-1 specify is upregulated in a TGF-Beta dependent manner in SSc and that inhibition of AP-1 reduces the collagen synthesis in SSc fibroblasts. The selective AP-1 inhibitor T-5224 efficiently prevented the development of dermal fibrosis in different mouse models of SSc. Thus, AP-1 might be a promising new molecular target for the treatment of SSc.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Arthritis & Rheumatism

ISSN

0004-3591

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1642-1652

UT code for WoS article

000303239000039

EID of the result in the Scopus database

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