Beta3 Adrenoceptors Substitute the Role of M-2 Muscarinic Receptor in Coping with Cold Stress in the Heart: Evidence from M2KO Mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11475" target="_blank" >RIV/00216208:11110/12:11475 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24610/12:#0000009
Result on the web
<a href="http://dx.doi.org/10.1007/s10571-011-9781-3" target="_blank" >http://dx.doi.org/10.1007/s10571-011-9781-3</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Beta3 Adrenoceptors Substitute the Role of M-2 Muscarinic Receptor in Coping with Cold Stress in the Heart: Evidence from M2KO Mice
Original language description
We investigated the role of beta3-adrenoceptors (AR) in cold stress (1 or 7 days in cold) in animals lacking main cardioinhibitive receptors-M2 muscarinic receptors (M2KO). There was no change in receptor number in the right ventricles. In the left ventricles, there was decrease in binding to all cardiostimulative receptors (beta1-, and beta2-AR) and increase in cardiodepressive receptors (beta3-AR) in unstressed KO in comparison to WT. The cold stress in WT animals resulted in decrease in binding to beta1- and beta2-AR (to 37%/35% after 1 day in cold and to 27%/28% after 7 days in cold) while beta3-AR were increased (to 216% of control) when 7 days cold was applied. MR were reduced to 46% and 58%, respectively. Gene expression of M2 MR in WT was not changed due to stress, while M3 was changed. The reaction of beta1- and beta2-AR (binding) to cold was similar in KO and WT animals, and beta3-AR in stressed KO animals did not change. Adenylyl cyclase activity was affected by beta3-agonis
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA309%2F09%2F0406" target="_blank" >GA309/09/0406: Muscarinic receptor regulation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cellular and Molecular Neurobiology
ISSN
0272-4340
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
859-869
UT code for WoS article
000305396900022
EID of the result in the Scopus database
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