Repeated Immobilization Stress Increases Expression of Beta(3)-Adrenoceptor in the Left Ventricle and Atrium of the Rat Heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10189804" target="_blank" >RIV/00216208:11110/14:10189804 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/smi.2515" target="_blank" >http://dx.doi.org/10.1002/smi.2515</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/smi.2515" target="_blank" >10.1002/smi.2515</a>
Alternative languages
Result language
angličtina
Original language name
Repeated Immobilization Stress Increases Expression of Beta(3)-Adrenoceptor in the Left Ventricle and Atrium of the Rat Heart
Original language description
Stress is a contributor of many cardiovascular diseases. Positive inotropic and chronotropic effects of catecholamines are regulated via Beta-adrenergic receptors (ARs). Many reports exist concerning changes of cardiac Beta1 - and Beta2 -ARs in stress, but only a few deal with modulation of cardiac Beta3 -AR. Our aim was to analyze the expression and binding sites of Beta1 -, Beta2 - and Beta3 -ARs and adenylyl cyclase activity in the left ventricle, and Beta3 -AR expression and binding in the left atrium of rats exposed to acute and chronic immobilization stress (IMO). The concentration of noradrenaline in the ventricle decreased, while adrenaline increased, especially after repeated IMO. The mRNA and protein levels, and binding sites of Beta3 -subtype significantly rose following chronic IMO, while all parameters for Beta2 -AR dropped after single and repeated exposure.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stress and Health
ISSN
1532-3005
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
301-309
UT code for WoS article
000343060600005
EID of the result in the Scopus database
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