Accounting for Movement Increases Sensitivity in Detecting Brain Activity in Parkinson's Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11530" target="_blank" >RIV/00216208:11110/12:11530 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/12:00194087 RIV/00064165:_____/12:11530

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0036271" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0036271</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Accounting for Movement Increases Sensitivity in Detecting Brain Activity in Parkinson's Disease

Original language description

Parkinson's disease (PD) is manifested by motor impairment, which may impede the ability to accurately perform motor tasks during functional magnetic resonance imaging (fMRI). Both temporal and amplitude deviations of movement performance affect the blood oxygenation level-dependent (BOLD) response. We present a general approach for assessing PD patients' movement control employing simultaneously recorded fMRI time series and behavioral data of the patients' kinematics using MR-compatible gloves. Twelvemale patients with advanced PD were examined with fMRI at 1.5T during epoch-based visually paced finger tapping. MR-compatible gloves were utilized online to quantify motor outcome in two conditions with or without dopaminergic medication. Modeling of individual-level brain activity included (i) a predictor consisting of a condition-specific, constant-amplitude boxcar function convolved with the canonical hemodynamic response function (HRF) as commonly used in fMRI statistics (standard

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GA309%2F09%2F1145" target="_blank" >GA309/09/1145: Mechanisms of deep brain stimulation: Role of the subthalamus in motor, visual and affective processing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

"nestrankovano"

UT code for WoS article

000305340700035

EID of the result in the Scopus database

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