P 024 - Near-infrared spectroscopy patterns of cortical activity during gait in Parkinson's disease patients treated with DBS STN

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10380430" target="_blank" >RIV/00216208:11110/18:10380430 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/18:00326471 RIV/00064165:_____/18:10380430

Result on the web

<a href="https://doi.org/10.1016/j.gaitpost.2018.06.181" target="_blank" >https://doi.org/10.1016/j.gaitpost.2018.06.181</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.gaitpost.2018.06.181" target="_blank" >10.1016/j.gaitpost.2018.06.181</a>

Result language

angličtina

Original language name

P 024 - Near-infrared spectroscopy patterns of cortical activity during gait in Parkinson's disease patients treated with DBS STN

Original language description

Disorders of gait seriously affect the functional state and quality of life of patients with Parkinson&apos;s disease (PD). Impaired brain function underlies disorders of movement control in PD, however functional brain imaging with magnetic resonance (fMRI) is not feasible during gait. Near-Infrared Spectroscopy (NIRS) is a portable imaging method for measuring brain activity. It uses low-energy optical radiation to detect local changes of (de)oxyhemoglobin concentration in the cerebral cortex, like a fMRI. We included 8 patients with advanced PD chronically treated with DBS STN. Brain activity was recorded with the NIRSport. Gait was examined in 10 cycles, during which the active and resting phases alternated. Changes in oxyhemoglobin concentration were calculated from the native NIRS signal using a modified transformation of the Lambert-Beer Law. The signals were filtered in the 0.015-0.3 Hz band and the least-squares algorithm was fitted with the HRF function for each cycle separately, from which the median was finally calculated. The activity of the motor cortex was significantly higher during gait in the OFF compared to ON state (p = 0.02). In contrast, in other regions no differences were found. A higher motor cortex activity shown in the DBS OFF compared to ON state may reflect the impairment of gait control in PD. In general terms, the present study demonstrates the potential utility of the NIRS method in detecting functional changes of the brain during gait in patients with PD

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV16-28119A" target="_blank" >NV16-28119A: Analysis of movement disorders for the study of extrapyramidal diseases mechanisms using motion capture camera systems</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gait and Posture

ISSN

0966-6362

e-ISSN

—

Volume of the periodical

65

Issue of the periodical within the volume

Supplement 1

Country of publishing house

IE - IRELAND

Number of pages

3

Pages from-to

273-275

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85050087318