Paraoxonase-1 (PON1) Status in Pancreatic Cancer: Relation to Clinical Parameters

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12291" target="_blank" >RIV/00216208:11110/12:12291 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/12:12291

Result on the web

<a href="http://fb.cuni.cz/file/5661/FB2012A0034.pdf" target="_blank" >http://fb.cuni.cz/file/5661/FB2012A0034.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Paraoxonase-1 (PON1) Status in Pancreatic Cancer: Relation to Clinical Parameters

Original language description

A group of 73 consecutive patients with PC (stage II?IV) and 73 control subjects were exam-ined. Laboratory studies included five polymorphisms of the PONl gene (L55M, Q192R, -108C/T, -126C/T, and-162A/G), PONl arylesterase (PON1-A) and lactonase (PONl-L) activities, as well as some markers of protein metabolism, insulin resistance, and oxidative stress. In comparison with the control group, no diťťerence in the distribution of the PONl polymorphisms was found in cancer patients, both arylesterase and lactonase activities being signifi-cantly lower (-33,-47 %, respectively, both P < 0.001). There was neither statistically signiheant association of PONl polymorphisms with tumour stages nor with diabetes mellitus connected with PC. The genotype distribution of L55M and -108C7T differed only in a subgroup of patients presenting clinically relevant malnutrition (x2== 6.50, 6.25, respectively, both P < 0.05). In the PC group, PONl-A and PONl-L activities correlated with Nutritional Risk Ind

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NS9769" target="_blank" >NS9769: Examination of antioxidant status and some polymorphisms of paraoxonase1 in patients with different diseases of pancreas</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

231-237

UT code for WoS article

000313920400002

EID of the result in the Scopus database

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