N-3 polyunsaturated fatty acids in psychiatric diseases: Mechanisms and clinical data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12579" target="_blank" >RIV/00216208:11110/12:12579 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/12:12579

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

N-3 polyunsaturated fatty acids in psychiatric diseases: Mechanisms and clinical data

Original language description

The lipids constitute majority of dry weight of mature human brain. From lipids, 35% is comprised of PUFA with long chain (LC-PUFA), especially docosahexaenoic acid (DHA) of n-3 family and arachidonic acid (AA) of n-6 family. Humans are dependent on dietary intake of both AA and DHA. Interestingly, the dietary n-6/n-3 ratio increased considerably during last century. LC-PUFAs play numerous roles in the brain, including structural (forming the physico-chemical properties in the lipid bilayer of cellularmembranes) and signaling ones. Moreover, they influence neurogenesis and neurotransmission within the nervous tissue. The metabolites of PUFA modulate immune and inflammatory processes in the brain, oxidative stress as well as its consequences. Of high importance is also their connection with several metabolic factors involved in the proper function of the brain and/or were discovered to play a role in the pathogenesis of neuropsychiatric diseases ? melatonin, homocysteine, leptin, and a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/NT13199" target="_blank" >NT13199: Selected genetic and nutritional factors in pathogenesis of metabolic syndrome: importance of polyunsaturated fatty acids.</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

8

Country of publishing house

SE - SWEDEN

Number of pages

13

Pages from-to

736-748

UT code for WoS article

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EID of the result in the Scopus database

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