Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13368" target="_blank" >RIV/00216208:11110/12:13368 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/12:00390178

Result on the web

<a href="http://dx.doi.org/10.1093/cvr/cvr314" target="_blank" >http://dx.doi.org/10.1093/cvr/cvr314</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium

Original language description

Aims The sinus venous myocardium, comprising the sinoatrial node (SAN) and sinus horns (SH), is a region subject to congenital malformations and cardiac arrhythmias. It differentiates from symmetric bilateral mesenchymal precursors, but morphological, molecular, and functional left/right differences are progressively established through development. The role of the laterality gene Pitx2 in this process is unknown. We aimed to elucidate the molecular events driving left/right patterning in the sinus venosus (SV) myocardium by using a myocardial Pitx2 knockout mouse. Methods and results We generated a myocardial specific Pitx2 knockout model (cTP mice). cTP embryos present several features of Pitx2 null, including right atrial isomerism with bilateral SANs and symmetric atrial entrance of the systemic veins. By in situ hybridization and optical mapping analysis, we compared throughout development the molecular and functional properties of the SV myocardium in wt and mutant embryos. We ob

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/GA304%2F08%2F0615" target="_blank" >GA304/08/0615: Molecular mechanisms of cardiac conduction system development</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cardiovascular Research

ISSN

0008-6363

e-ISSN

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Volume of the periodical

93

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

291-301

UT code for WoS article

000299415900013

EID of the result in the Scopus database

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