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Multiple Roles of Pitx2 in Cardiac Development and Disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00506622" target="_blank" >RIV/67985823:_____/17:00506622 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/17:10373132

  • Result on the web

    <a href="https://www.mdpi.com/2308-3425/4/4/16" target="_blank" >https://www.mdpi.com/2308-3425/4/4/16</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/jcdd4040016" target="_blank" >10.3390/jcdd4040016</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Multiple Roles of Pitx2 in Cardiac Development and Disease

  • Original language description

    Cardiac development is a complex morphogenetic process initiated as bilateral cardiogenic mesoderm is specified at both sides of the gastrulating embryo. Soon thereafter, these cardiogenic cells fuse at the embryonic midline configuring a symmetrical linear cardiac tube. Left/right bilateral asymmetry is first detected in the forming heart as the cardiac tube bends to the right, and subsequently, atrial and ventricular chambers develop. Molecular signals emanating from the node confer distinct left/right signalling pathways that ultimately lead to activation of the homeobox transcription factor Pitx2 in the left side of distinct embryonic organ anlagen, including the developing heart. Asymmetric expression of Pitx2 has therefore been reported during different cardiac developmental stages, and genetic deletion of Pitx2 provided evidence of key regulatory roles of this transcription factor during cardiogenesis and thus congenital heart diseases. More recently, impaired Pitx2 function has also been linked to arrhythmogenic processes, providing novel roles in the adult heart. In this manuscript, we provide a state-of-the-art review of the fundamental roles of Pitx2 during cardiogenesis, arrhythmogenesis and its contribution to congenital heart diseases.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30106 - Anatomy and morphology (plant science to be 1.6)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of cardiovascular development and disease

  • ISSN

    2308-3425

  • e-ISSN

  • Volume of the periodical

    4

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    19

  • Pages from-to

    16

  • UT code for WoS article

    000457906400001

  • EID of the result in the Scopus database