Multiple Roles of Pitx2 in Cardiac Development and Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10373132" target="_blank" >RIV/00216208:11110/17:10373132 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/17:00506622

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753117/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753117/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcdd4040016" target="_blank" >10.3390/jcdd4040016</a>

Result language

angličtina

Original language name

Multiple Roles of Pitx2 in Cardiac Development and Disease

Original language description

Cardiac development is a complex morphogenetic process initiated as bilateral cardiogenic mesoderm is specified at both sides of the gastrulating embryo. Soon thereafter, these cardiogenic cells fuse at the embryonic midline configuring a symmetrical linear cardiac tube. Left/right bilateral asymmetry is first detected in the forming heart as the cardiac tube bends to the right, and subsequently, atrial and ventricular chambers develop. Molecular signals emanating from the node confer distinct left/right signalling pathways that ultimately lead to activation of the homeobox transcription factor Pitx2 in the left side of distinct embryonic organ anlagen, including the developing heart. Asymmetric expression of Pitx2 has therefore been reported during different cardiac developmental stages, and genetic deletion of Pitx2 provided evidence of key regulatory roles of this transcription factor during cardiogenesis and thus congenital heart diseases. More recently, impaired Pitx2 function has also been linked to arrhythmogenic processes, providing novel roles in the adult heart. In this manuscript, we provide a state-of-the-art review of the fundamental roles of Pitx2 during cardiogenesis, arrhythmogenesis and its contribution to congenital heart diseases.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30106 - Anatomy and morphology (plant science to be 1.6)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cardiovascular Development and Disease

ISSN

2308-3425

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

19

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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