APOA5 haplotypes determine triglyceride decrease after lifestyle induced weight loss in children

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13478" target="_blank" >RIV/00216208:11110/12:13478 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/12:00055974 RIV/00064165:_____/12:13478
Result on the web
<a href="http://dx.doi.org/10.1016/j.numecd.2012.05.001" target="_blank" >http://dx.doi.org/10.1016/j.numecd.2012.05.001</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
APOA5 haplotypes determine triglyceride decrease after lifestyle induced weight loss in children
Original language description
Principal finding of our study, one of the largest in paediatric/adolescent obese patients, and the only one focused on APOA5 tagging SNPs, is the significant interaction between intensive and comprehensive lifestyle changes and APOA5 haplotypes leadingto more favourable changes of plasma TG concentrations in carriers of the minor "risk" alleles when compared to the common homozygotes. Interestingly, post-intervention levels of plasma TGs were almost identical between these two groups. This finding isof major importance suggesting that, at least to some extent, the impact of negative genetic predispositions could be overrun by comprehensive lifestyle changes.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/NS10589" target="_blank" >NS10589: Genetic and factors of life style by children with metabolic syndrom and their dependents. Diagnostic and interference.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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