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Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q-syndrome and in Diamond-Blackfan anemia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A00013501" target="_blank" >RIV/00216208:11110/13:00013501 - isvavai.cz</a>

  • Alternative codes found

    RIV/00098892:_____/13:#0000605 RIV/00023736:_____/13:00010001 RIV/00064165:_____/13:00013501

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s00277-012-1568-1" target="_blank" >http://dx.doi.org/10.1007/s00277-012-1568-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00277-012-1568-1" target="_blank" >10.1007/s00277-012-1568-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q-syndrome and in Diamond-Blackfan anemia

  • Original language description

    Friend leukemia virus integration 1 (Fli1) and erythroid Krüppel-like factor (EKLF) participate under experimental conditions in the differentiation of megakaryocytic and erythroid progenitor in cooperation with other transcription factors, cytokines, cytokine receptors, and microRNAs. Defective erythropoiesis with refractory anemia and effective megakaryopoiesis with normal or increased platelet count is typical for 5q- syndrome. We decided to evaluate the roles of EKLF and Fli1 in the pathogenesis ofthis syndrome and of another ribosomopathy, Diamond-Blackfan anemia (DBA).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT13836" target="_blank" >NT13836: The study of the myelodysplastic syndrome pathogenesis in patients with isolated del(5q) abnormality and the analysis of the effect of lenalidomide</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Annals of Hematology

  • ISSN

    0939-5555

  • e-ISSN

  • Volume of the periodical

    92

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    11-18

  • UT code for WoS article

    000313068700002

  • EID of the result in the Scopus database