Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10134358" target="_blank" >RIV/00216208:11110/13:10134358 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00396918 RIV/00216208:11310/13:10134358 RIV/00023001:_____/13:00058547
Result on the web
<a href="http://dx.doi.org/10.1152/ajpheart.00679.2012" target="_blank" >http://dx.doi.org/10.1152/ajpheart.00679.2012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/ajpheart.00679.2012" target="_blank" >10.1152/ajpheart.00679.2012</a>
Alternative languages
Result language
angličtina
Original language name
Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo
Original language description
A significant increase in cardiovascular medication use during pregnancy occurred in recent years. Only limited evidence on safety profiles is available, and little is known about the mechanisms of adverse effect on the fetus. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. Embryotoxicity was tested in ovo after administration of various doses of metoprolol, carvedilol, or ivabradine. Embryonic day (ED) 4 and 8 chick embryos were studied by video microscopy and ultrasound biomicroscopy ex ovo after intraamniotic injection of the drug for a period of 30 min. Stroke volume was calculated by the Simpson method and prolate ellipsoid formula. Significant dose-dependent mortality was achieved in embryos injected with carvedilol and ivabradine. In ED4 embryos, metoprolol, carvedilol, and ivabradine reduced the heart rate by 33%, 27%, and 55%, respectively, compared with controls (6%). In ED8 embryos this effect was more pronounced with a heart
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology - Heart and Circulatory Physiology
ISSN
0363-6135
e-ISSN
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Volume of the periodical
304
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
"H895"-"H902"
UT code for WoS article
000316206400013
EID of the result in the Scopus database
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