Pheochromocytoma and Markers of Oxidative Stress

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189073" target="_blank" >RIV/00216208:11110/13:10189073 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10189073

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/62/62_331.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/62/62_331.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Pheochromocytoma and Markers of Oxidative Stress

Original language description

High levels of catecholamines in pheochromocytoma (PHEO) are associated with risk of cardiovascular complications. In this study, we looked for potential differences in markers of oxidative stress - vitamin C, superoxide dismutase (SOD) and malondialdehyde (MDA) in PHEO before and after the operation. We studied 18 subjects with PHEO who were examined before and approximately one year after the successful tumor removal (free of disease). All subjects had elevated urinary epinephrine and/or norepinephrine levels before the operation. Vitamin C levels increased significantly after the operation from 61 +/- 27 to 77 +/- 20 mu mol/l (P=0.02), and MDA decreased significantly after the tumor removal from 2.6 +/- 0.4 to 2.0 +/- 0.6 mu mol/l (P=0.01). However,no changes were found in SOD activity before and after the operation. In conclusion, increased catecholamine production in PHEO is accompanied by decreased levels of vitamin C and increased levels of MDA which may indicate the activation

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/NT12336" target="_blank" >NT12336: Chromogranin, metanephrines and thyroid factors in the differential diagnosis of neuroendocrine tumors directed to the medullary carcinoma of the thyroid gland and pheochromocytoma</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

331-335

UT code for WoS article

000321322900012

EID of the result in the Scopus database

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