The impairment of lysyl oxidase in keratoconus and in keratoconus-associated disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10192042" target="_blank" >RIV/00216208:11110/13:10192042 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00702-013-0993-1" target="_blank" >http://dx.doi.org/10.1007/s00702-013-0993-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-013-0993-1" target="_blank" >10.1007/s00702-013-0993-1</a>

Result language

angličtina

Original language name

The impairment of lysyl oxidase in keratoconus and in keratoconus-associated disorders

Original language description

Keratoconus (KC) is an eye disease characterized by the progressive thinning and protrusion of the cornea, which results in the loss of visual acuity. This disorder remains poorly understood, although recent studies indicate the involvement of genetic and environmental factors. Recently, we have found that the distribution of the cross-linking enzyme lysyl oxidase (LOX) is markedly decreased in about 63 % of keratoconic specimens. Similarly, LOX activity is significantly reduced by 38 % compared to control tissue. Nearly 70 systemic disorders have been reported in association with KC, most of them affecting the extracellular matrix. In this review we attempted to ascertain whether any KC-associated diseases exhibit signs that may reflect LOX impairment. We hypothesized that very similar changes in the extracellular matrix, particularly at the level of collagen metabolism, including LOX impairment in mitral leaflets, may reflect an association between KC and mitral valve prolapse. Moreo

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Volume of the periodical

120

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

977-982

UT code for WoS article

000319433000018

EID of the result in the Scopus database

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