Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12625" target="_blank" >RIV/00216208:11110/12:12625 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21340/12:00197495 RIV/00064165:_____/12:12625
Result on the web
<a href="http://dx.doi.org/10.1016/j.exer.2012.09.005" target="_blank" >http://dx.doi.org/10.1016/j.exer.2012.09.005</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas
Original language description
Inadequate cross-linking between collagens is a characteristic feature of keratoconus (KC). The formation of bonds between collagen and elastin fibrils is mediated by the lysyl oxidase (LOX) and 4 LOX-like enzymes. The aim of this study was to determinethe distribution of LOX and the total LOX activity (LOX and 4 LOX-like enzymes) in control and KC corneas. The distribution of LOX was clearly decreased in at least 5 of the 8 KC specimens. The most marked signal reduction was observed in the stromal matrix and in keratocytes. The signal in KC specimens revealed a more irregular pattern. Endothelial cells showed no or very weak staining in areas just beneath negative stromal tissue. The mean activity of total LOX in the KC samples was lower than in control tissue and the decrease was statistically significant (p = 0.0178). We hypothesize that the restricted LOX distribution in KC corneas, and particularly the decrease of total LOX activity in cultured keratoconic fibroblasts, is one pot
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GPP301%2F12%2FP591" target="_blank" >GPP301/12/P591: Identification and characterization of a novel gene causing corneal endothelial dystrophies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Eye Research
ISSN
0014-4835
e-ISSN
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Volume of the periodical
104
Issue of the periodical within the volume
NOV 2012
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
74-81
UT code for WoS article
000311133400009
EID of the result in the Scopus database
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