The Cysteine Dioxgenase Knockout Mouse: Altered Cysteine Metabolism in Nonhepatic Tissues Leads to Excess H2S/HS- Production and Evidence of Pancreatic and Lung Toxicity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193137" target="_blank" >RIV/00216208:11110/13:10193137 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/13:10193137
Result on the web
<a href="http://dx.doi.org/10.1089/ars.2012.5010" target="_blank" >http://dx.doi.org/10.1089/ars.2012.5010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/ars.2012.5010" target="_blank" >10.1089/ars.2012.5010</a>
Alternative languages
Result language
angličtina
Original language name
The Cysteine Dioxgenase Knockout Mouse: Altered Cysteine Metabolism in Nonhepatic Tissues Leads to Excess H2S/HS- Production and Evidence of Pancreatic and Lung Toxicity
Original language description
Aims: To define the consequences of loss of cysteine dioxygenase (CDO) on cysteine metabolism at the tissue level, we determined levels of relevant metabolites and enzymes and evidence of H2S/HS- (gaseous hydrogen sulfide and its conjugate base) toxicityin liver, pancreas, kidney, and lung of CDO-/- mice that were fed either a taurine-free or taurine-supplemented diet. Results: CDO-/- mice had low tissue and serum taurine and hypotaurine levels and high tissue levels of cysteine, consistent with the loss of CDO. CDO-/- mice had elevated urinary excretion of thiosulfate, high tissue and serum cystathionine and lanthionine levels, and evidence of inhibition and destabilization of cytochrome c oxidase, which is consistent with excess production of H2S/HS-. Accumulation of cystathionine and lanthionine appeared to result from cystathionine -synthase (CBS)-mediated cysteine desulfhydration. Very high levels of hypotaurine in pancreas of wild-type mice and very high levels of cystathionine
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Antioxidants and Redox Signaling
ISSN
1523-0864
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
1321-1336
UT code for WoS article
000325267800002
EID of the result in the Scopus database
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