The possible role of dermatophyte cysteine dioxygenase in keratin degradation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33143896" target="_blank" >RIV/61989592:15110/13:33143896 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/13693786.2013.794310" target="_blank" >http://dx.doi.org/10.3109/13693786.2013.794310</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/13693786.2013.794310" target="_blank" >10.3109/13693786.2013.794310</a>
Alternative languages
Result language
angličtina
Original language name
The possible role of dermatophyte cysteine dioxygenase in keratin degradation
Original language description
Cysteine dioxygenase (CDO, EC 1.13.11.20) is a key enzyme involved in the homeostatic regulation of cysteine level and in production of important oxidized metabolites of cysteine such as pyruvate, sulphite, sulphate, hypotaurine, and taurine in all eukaryotic cells. The intracellular CDO concentration is regulated at both transcriptional and posttranslational levels. In several fungi, CDO plays an important role as a virulence factor involved in morphological transition from yeast to mycelial forms. CDOis crucial for oxidation of cysteine to cysteine sulphinic acid and therefore for sulphite production and secretion. Because sulphite cleaves disulphide bridges as a fi rst unavoidable step in keratinolysis, it is hypothesized that in dermatophytes, CDOis a virulence factor crucial for keratin degradation.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.3.20.0164" target="_blank" >EE2.3.20.0164: International research network</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medical Mycology
ISSN
1369-3786
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
449-454
UT code for WoS article
000320320400001
EID of the result in the Scopus database
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