Fine needle aspiration biopsy proves increased T-lymphocyte proliferation in tumor and decreased metastatic infiltration after treatment with doxorubicin bound to PHPMA copolymer carrier

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193707" target="_blank" >RIV/00216208:11110/13:10193707 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/13:00396051 RIV/61389013:_____/13:00396051 RIV/00064203:_____/13:10193707
Result on the web
<a href="http://dx.doi.org/10.3109/1061186X.2013.792345" target="_blank" >http://dx.doi.org/10.3109/1061186X.2013.792345</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/1061186X.2013.792345" target="_blank" >10.3109/1061186X.2013.792345</a>

Result language
angličtina
Original language name
Fine needle aspiration biopsy proves increased T-lymphocyte proliferation in tumor and decreased metastatic infiltration after treatment with doxorubicin bound to PHPMA copolymer carrier
Original language description
Introduction: Fine needle aspiration biopsy (FNAB) is an easy method with an option of repetitive withdrawal of cell material. Methods: First, mice were inoculated with mouse T-lymphoma, after 10 d the samples from tumor, lymph nodes and spleen gained byFNAB and excision were analyzed by flow cytometry. Tumor progression was compared to the control group simultaneously. Then, 10 d after tumor cell inoculation free doxorubicin (DOX) or different PHPMA DOX conjugates were injected. Cell material was analyzed to detect subpopulations of lymphocyte infiltrate, and levels of cytokines in correlation with progression or regression of the disease. Results: FNAB has no influence on the tumor's growth or survival of experimental animals. After treatment with PHPMA conjugates there was a significant increase of T-lymphocyte subpopulations in tumor microenvironment compared to controls or free DOX, but only in mice with confirmed macroscopic regression of tumor within two weeks. Mice treated wit
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/GAP301%2F12%2F1254" target="_blank" >GAP301/12/1254: Overcoming Natural and Multidrug Resistance by Tumor-Selective Delivery of ABC Transporter/Bcl-2 Inhibitors or Therapeutic Gene under PEG-3 Promoter</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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