RGDS - and doxorubicin-modified poly[N-(2-hydroxypropyl) methacrylamide]-coated gamma-Fe2O3 nanoparticles.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F21%3A00001059" target="_blank" >RIV/61383082:_____/21:00001059 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s00396-021-04895-6" target="_blank" >https://link.springer.com/article/10.1007/s00396-021-04895-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00396-021-04895-6" target="_blank" >10.1007/s00396-021-04895-6</a>
Alternative languages
Result language
angličtina
Original language name
RGDS - and doxorubicin-modified poly[N-(2-hydroxypropyl) methacrylamide]-coated gamma-Fe2O3 nanoparticles.
Original language description
Block copolymer comprising of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHP) and reactive poly[N-(2-hydrazinyl-2-oxoethyl)methacrylamide] (PMAH) was synthesized by a reversible addition-fragmentation chain transfer (RAFT) polymerization and conjugated with doxorubicin (Dox) and/or RGDS targeting peptide via one-step reaction using N-gamma-maleimidobutyryl-oxysuccinimide ester. The resulting copolymer served as a coating of magnetic gamma-Fe2O3 nanoparticles that were tested in cell proliferation and in vivo experiments on a mice model with inoculated rat C6 glioblastoma tumor. The nanoparticles conjugated with RGDS peptide and doxorubicin easily engulfed both C6 tumor cell line, primary glioblastoma (GB) cells, and human mesenchymal stem cells (hMSC) used as a control; the particles decreased the GB cell growth by 45% compared to control cells without any treatment. Moreover, the gamma-Fe2O3@P(HP-MAH)-RGDS-Dox nanoparticles injected into C6 glioblastoma cell-derived tumors grown in the posterior flank of mice decreased the tumor size and more apoptotic cells were spread compared to that treated with free Dox.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
COLLOID AND POLYMER SCIENCE
ISSN
0303-402X
e-ISSN
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Volume of the periodical
2021
Issue of the periodical within the volume
Oct2021
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1-11
UT code for WoS article
000702787800001
EID of the result in the Scopus database
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