Poly[N‐(2‐hydroxypropyl)methacrylamide]‐modified magnetic .gamma.‐F2O3 nanoparticles conjugated with doxorubicin for glioblastoma treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00519564" target="_blank" >RIV/61389013:_____/20:00519564 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/20:00519564 RIV/61383082:_____/20:00000689 RIV/00216208:11110/20:10400428 RIV/00216208:11130/20:10400428
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.201900564" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.201900564</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmdc.201900564" target="_blank" >10.1002/cmdc.201900564</a>
Alternative languages
Result language
angličtina
Original language name
Poly[N‐(2‐hydroxypropyl)methacrylamide]‐modified magnetic .gamma.‐F2O3 nanoparticles conjugated with doxorubicin for glioblastoma treatment
Original language description
With the aim to develop a new anticancer agent, we prepared poly[N‐(2‐hydroxypropyl)methacrylamide‐co‐methyl 2‐methacrylamidoacetate] [P(HP‐MMAA)], which was reacted with hydrazine to poly[N‐(2‐hydroxypropyl)methacrylamide‐co‐N‐(2‐hydrazinyl‐2‐oxoethyl)methacrylamide] [P(HP‐MAH)] to conjugate doxorubicin (Dox) via hydrazone bond. The resulting P(HP‐MAH)‐Dox conjugate was used as a coating of magnetic γ‐Fe2O3 nanoparticles obtained by the coprecipitation method. In vitro toxicity of various concentrations of Dox, P(HP‐MAH)‐Dox, and γ‐Fe2O3@P(HP‐MAH)‐Dox nanoparticles was determined on somatic healthy cells (human bone marrow stromal cells hMSC), human glioblastoma line (GaMG), and primary human glioblastoma (GBM) cells isolated from GBM patients both at a short and prolonged exposition time (up to 7 days). Due to hydrolysis of the hydrazone bond in acid milieu of tumor cells and Dox release, the γ‐Fe2O3@P(HP‐MAH)‐Dox nanoparticles significantly decreased the GaMG and GBM cell growth compared to free Dox and P(HP‐MAH)‐Dox in low concentration (10 nM), whereas in hMSCs it remained without effect. γ‐F2O3@PHP nanoparticles alone did not affect the viability of any of the tested cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA17-04918S" target="_blank" >GA17-04918S: Treating Glioblastoma with surface engineered superparamagnetic iron oxide nanoparticles for efficient conjugation with anticancer drugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemMedChem
ISSN
1860-7179
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
96-104
UT code for WoS article
000495798800001
EID of the result in the Scopus database
2-s2.0-85075201973