RGDS- and doxorubicin-modified poly[N-(2-hydroxypropyl)methacrylamide]-coated .gamma.-Fe2O3 nanoparticles for treatment of glioblastoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00556055" target="_blank" >RIV/61389013:_____/22:00556055 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/22:00556055 RIV/00216208:11110/22:10432518 RIV/00216208:11130/22:10432518
Result on the web
<a href="https://link.springer.com/article/10.1007/s00396-021-04895-6" target="_blank" >https://link.springer.com/article/10.1007/s00396-021-04895-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00396-021-04895-6" target="_blank" >10.1007/s00396-021-04895-6</a>

Result language
angličtina
Original language name
RGDS- and doxorubicin-modified poly[N-(2-hydroxypropyl)methacrylamide]-coated .gamma.-Fe2O3 nanoparticles for treatment of glioblastoma
Original language description
Block copolymer comprising of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHP) and reactive poly[N-(2-hydrazinyl-2-oxoethyl)methacrylamide] (PMAH) was synthesized by a reversible addition-fragmentation chain transfer (RAFT) polymerization and conjugated with doxorubicin (Dox) and/or RGDS targeting peptide via one-step reaction using N-γ-maleimidobutyryl-oxysuccinimide ester. The resulting copolymer served as a coating of magnetic γ-Fe2O3 nanoparticles that were tested in cell proliferation and in vivo experiments on a mice model with inoculated rat C6 glioblastoma tumor. The nanoparticles conjugated with RGDS peptide and doxorubicin easily engulfed both C6 tumor cell line, primary glioblastoma (GB) cells, and human mesenchymal stem cells (hMSC) used as a control. The particles decreased the GB cell growth by 45% compared to control cells without any treatment. Moreover, the γ-Fe2O3@P(HP-MAH)-RGDS-Dox nanoparticles injected into C6 glioblastoma cell-derived tumors grown in the posterior flank of mice decreased the tumor size and more apoptotic cells were spread compared to that treated with free Dox.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)