Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10194763" target="_blank" >RIV/00216208:11110/13:10194763 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00440589
Result on the web
<a href="http://dx.doi.org/10.1111/boc.201300022" target="_blank" >http://dx.doi.org/10.1111/boc.201300022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/boc.201300022" target="_blank" >10.1111/boc.201300022</a>
Alternative languages
Result language
angličtina
Original language name
Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding
Original language description
Background Information A Polycomb (PcG) body is an orphan nuclear subcompartment characterised by accumulations of Polycomb repressive complex 1 (PRC1) proteins. However, seemingly contradictory reports have appeared that describe the PcG bodies either as protein-based bodies in the interchromatin compartment or chromatin domains. In this respect, molecular crowding is an important factor for the assembly and stability of nuclear subcompartments. In order to settle this contradiction, crowding experiments, that represent a convenient model distinguishing between interchromatin and chromatin compartments, were carried out. Results In sucrose-hypertonically induced crowding, we observed in U-2 OS cells that PcG bodies disappeared, but persisted as nuclear domains characterised by accumulations of DNA. This phenomenon was also observed in cells hypertonically treated with sorbitol and NaCl. Importantly, the observed changes were quickly reversible after re-incubation of cells in normal me
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biology of the Cell
ISSN
0248-4900
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
519-534
UT code for WoS article
000330038400002
EID of the result in the Scopus database
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