Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F12%3A00059085" target="_blank" >RIV/00216224:14330/12:00059085 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00376788
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jcp.22912/suppinfo" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jcp.22912/suppinfo</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jcp.22912" target="_blank" >10.1002/jcp.22912</a>
Alternative languages
Result language
angličtina
Original language name
Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin
Original language description
Polycomb group (PcG) proteins, organized into Polycomb bodies, are important regulatory components of epigenetic processes involved in the heritable transcriptional repression of target genes. Here, we asked whether acetylation can influence the nucleararrangement and function of the BMI1 protein, a core component of the Polycomb group complex, PRC1. We used time-lapse confocal microscopy, micro-irradiation by UV laser (355 nm) and GFP technology to study the dynamics and function of the BMI1 protein.Our data indicate that the dynamics of recognition of UV-damaged chromatin, and the nuclear arrangement of BMI1 protein can be influenced by acetylation and occur as an early event prior to the recruitment of HPb to UV-irradiated chromatin.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of cellular physiology
ISSN
0021-9541
e-ISSN
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Volume of the periodical
227
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1838-1850
UT code for WoS article
000299373900008
EID of the result in the Scopus database
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