Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272326" target="_blank" >RIV/00216208:11110/14:10272326 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10272326
Result on the web
<a href="http://dx.doi.org/10.1136/jnnp-2013-307106" target="_blank" >http://dx.doi.org/10.1136/jnnp-2013-307106</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/jnnp-2013-307106" target="_blank" >10.1136/jnnp-2013-307106</a>
Alternative languages
Result language
angličtina
Original language name
Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes
Original language description
Objectives: There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. Methods: ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1+-SD 8.1 years). All patients were treated with intramuscular interferon-? as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-? treatment. Results: Greater ApoB levels were associated with increased number of new T2 lesions (p<0.001) and increased number of new or enlarging T2 lesions (p<0.001
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13237" target="_blank" >NT13237: Clinical and paraclinical markers of multiple sclerosis – description and prediction of disease activity</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurology, Neurosurgery and Psychiatry
ISSN
0022-3050
e-ISSN
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Volume of the periodical
85
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
860-865
UT code for WoS article
000342428500052
EID of the result in the Scopus database
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