Serum Cortisol Seems To Be a More Appropriate Marker for Adrenocortical Reserve Evaluation in ACTH Test in Comparison to Salivary Cortisol

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10281302" target="_blank" >RIV/00216208:11110/14:10281302 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/14:#0000460 RIV/00064165:_____/14:10281302

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/63/63_229.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/63/63_229.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Serum Cortisol Seems To Be a More Appropriate Marker for Adrenocortical Reserve Evaluation in ACTH Test in Comparison to Salivary Cortisol

Original language description

Salivary cortisol reflects the free fraction of serum cortisol. Monitoring salivary cortisol may be a promising alternative method for assessing serum cortisol in some clinical situations. We aimed to compare the reliability of salivary vs. serum cortisol during ACTH test. 84 subjects (mean age 63.2; 24-89 years; n=66 males) suspected for adrenocortical insufficiency underwent an ACTH test. Patients were divided based on peak serum cortisol into hypocortical group with cortisol <500 nmol/l and to reference group cortisol <500 nmol/l. Median serum cortisol levels in reference group were 445, 766, and 902 nmol/l at 0, 30, and 60 minutes, respectively, and in hypocortical group were 256, 394, and 453 nmol/l. Median salivary cortisol levels were 19.02, 40.02, and 62.1 nmol/l in reference group, and 9.60, 14.08, and 13.28 nmol/l in hypocortical group. Obtained values showed good correlation between serum and salivary cortisol (p<0.0001). The percentage of explained variability R-2 (coeffici

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT11277" target="_blank" >NT11277: Standardization of dynamic tests of hypocorticalism</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

229-236

UT code for WoS article

000336459800010

EID of the result in the Scopus database

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