Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282874" target="_blank" >RIV/00216208:11110/14:10282874 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10282874
Result on the web
<a href="http://dx.doi.org/10.1016/j.jns.2014.10.002" target="_blank" >http://dx.doi.org/10.1016/j.jns.2014.10.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jns.2014.10.002" target="_blank" >10.1016/j.jns.2014.10.002</a>

Result language
angličtina
Original language name
Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment
Original language description
Background: Repeated administration of Paced Auditory Serial Addition Test (PASAT) results in a considerable learning effect in short- or long-term follow-up studies. However, the relationship between PASAT learning and changes in magnetic resonance imaging (MRI) parameters is yet to be investigated. Objectives: The aim of this study is to determine if change in brain MRI metrics predicts evolution of PASAT in high functioning clinically isolated syndrome (CIS) patients on disease-modifying treatment (DMT). Methods: This prospective 48-month observational study examined 128 CIS patients treated with 30. ?g of intramuscular interferon beta-1a once a week. The correlation between PASAT and MRI measures was assessed at baseline, at 6. months and then annually over the 48-month follow up. Linear mixed model analysis adjusted for age, gender, education and DMT was used to model the temporal association between MRI measures and PASAT performance. Results: MRI revealed 2.5% gray matter (GM) v
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NT13237" target="_blank" >NT13237: Clinical and paraclinical markers of multiple sclerosis – description and prediction of disease activity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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