Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of beta-Amyloid Peptides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10283560" target="_blank" >RIV/00216208:11110/14:10283560 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/14:00434370
Result on the web
<a href="http://dx.doi.org/10.1002/mabi.201400249" target="_blank" >http://dx.doi.org/10.1002/mabi.201400249</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.201400249" target="_blank" >10.1002/mabi.201400249</a>
Alternative languages
Result language
angličtina
Original language name
Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of beta-Amyloid Peptides
Original language description
Identification and evaluation of small changes in beta-amyloid peptide (A beta) levels in cerebrospinal fluid is of crucial importance for early detection of Alzheimer's disease. Microfluidic detection methods enable effective preconcentration of Ab using magnetic microparticles coated with Ab antibodies. Poly-(glycidyl methacrylate) microspheres are coated with alpha-amino-omega-methoxy-PEG(5000)/alpha-amino-omega-Boc-NH-PEG(5000) Boc groups deprotected and NH2 succinylated to introduce carboxyl groups. Capillary electrophoresis with laser-induced fluorescence detection confirms the efficient capture of A beta 1-40 peptides on the microspheres with immobilized monoclonal anti-A beta 6E10. The capture specificity is confirmed by comparing A beta 1-40 levels on the anti-IgG-immobilized particles used as a control.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/7E12053" target="_blank" >7E12053: Nanosystems for early Diagnosis of Neurodegenerative Diseases</a><br>
Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Bioscience
ISSN
1616-5187
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
1590-1599
UT code for WoS article
000344749200009
EID of the result in the Scopus database
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