Characteristics and occurrence of speech impairment in Huntington's disease: possible influence of antipsychotic medication

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284398" target="_blank" >RIV/00216208:11110/14:10284398 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/14:00221819 RIV/00064165:_____/14:10284398

Result on the web

<a href="http://dx.doi.org/10.1007/s00702-014-1229-8" target="_blank" >http://dx.doi.org/10.1007/s00702-014-1229-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-014-1229-8" target="_blank" >10.1007/s00702-014-1229-8</a>

Result language

angličtina

Original language name

Characteristics and occurrence of speech impairment in Huntington's disease: possible influence of antipsychotic medication

Original language description

Although motor speech impairment is a common manifestation of Huntington's disease (HD), its description remains limited. The aim of the current study was therefore to estimate the occurrence and characteristics of speech disorder in HD and to explore the influence of antipsychotic medication on speech performance. Speech samples, including reading passage and monologue, were acquired from 40 individuals diagnosed with HD and 40 age- and sex-matched healthy controls. Objective acoustic analyses were used to evaluate key aspects of speech including vowel articulation, intensity, pitch and timing. A predictive model was constructed to detect the occurrence and most prominent patterns of speech dysfunction in HD. We revealed that 93 % of HD patients manifest some degree of speech impairment. Decreased number of pauses, slower articulation rate, imprecise vowel articulation and excess intensity variations were found to be the most salient patterns of speech dysfunction in HD. We further de

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Volume of the periodical

121

Issue of the periodical within the volume

12

Country of publishing house

AT - AUSTRIA

Number of pages

11

Pages from-to

1529-1539

UT code for WoS article

000345409000007

EID of the result in the Scopus database

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