Could Antipsychotic Medication Influence Speech In Huntington?s Disease?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F14%3A00219873" target="_blank" >RIV/68407700:21230/14:00219873 - isvavai.cz</a>
Result on the web
<a href="http://jnnp.bmj.com/content/85/Suppl_1/A71.1.abstract?sid=757c8a68-2146-4296-a203-31c2fb275b77" target="_blank" >http://jnnp.bmj.com/content/85/Suppl_1/A71.1.abstract?sid=757c8a68-2146-4296-a203-31c2fb275b77</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/jnnp-2014-309032.200" target="_blank" >10.1136/jnnp-2014-309032.200</a>
Alternative languages
Result language
angličtina
Original language name
Could Antipsychotic Medication Influence Speech In Huntington?s Disease?
Original language description
Background Hyperkinetic dysarthria is a common sign of Huntington?s disease (HD). Although antipsychotic medication alone can induce hyperkinetic dysarthria, its effect on speech in HD remains unknown. Aim The aim of the current study was to survey if antipsychotic medication can influence speech in HD. Methods We studied 40 patients diagnosed with HD, 22 of them were treated with antipsychotic medication (HD-AP) whereas 18 patients received no antipsychotic therapy (HD-NoAP). As controls, 40 age- and sex-matched healthy subjects were also investigated. All participants performed short reading passage for subsequent quantitative acoustic analyses of vowel articulation, intensity, pitch, and speech timing. Results When compared to controls, both HD-AP and HD-NoAP patients demonstrated significantly slower articulation rate and decreased number of pauses (p < 0.001). HD-NoAp group showed significantly decreased pitch variation (p < 0.05) whereas intensity variation was increased in HD-AP
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP102%2F12%2F2230" target="_blank" >GAP102/12/2230: Acoustic voice and speech analysis in patients with central nervous system disorders</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů