Plasma free metanephrines in diagnostics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10295221" target="_blank" >RIV/00216208:11110/14:10295221 - isvavai.cz</a>
Result on the web
<a href="http://www.ce-ce.org/CECE2014/CECE%202014%20proceedings_full.pdf" target="_blank" >http://www.ce-ce.org/CECE2014/CECE%202014%20proceedings_full.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Plasma free metanephrines in diagnostics
Original language description
Quantitative determination of catecholamines and their O-methyl metabolites (metanephrines) plays an important role in the diagnosis of pheochromocytoma (PHEO) - adrenal medulla tumour. The most common symptom of this kind of tumour is hypertension (high blood pressure). PHEO synthesizes, stocks, metabolizes and mostly secretes catecholamines. For this reason it is possible to use significantly elevated concentrations of catecholamines and their metabolic products as diagnostic markers of this tumour. The determination of metanephrines, mainly normetanephrine (NMN), metanephrine (MN) and 3-methoxytyramine (3-MT), is preferred against the determination of catecholamines because tumour cells produce free metanephrines continuously and irrespective of the release of catecholamines. The project aims to develop a new kit for the determination of plasma metanephrines. Solid phase extraction (SPE) is used for the pre-treatment of plasma samples. The determination is performed by ion-pair ultra-high performance liquid chromatography with electrochemical detection (UHPLC-ED).
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/FR-TI4%2F331" target="_blank" >FR-TI4/331: *The development of a plasma free metanephrine analysis kit</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
CECE 2014: 11th International Interdisciplinary Meeting on Bioanalysis
ISBN
978-80-904959-2-0
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
361-364
Publisher name
Institute of Analytical Chemistry AS CR
Place of publication
Brno
Event location
Brno
Event date
Oct 20, 2014
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000354547400117