Polymorphisms of the receptor for advanced glycation end-products and glyoxalase I in patients with renal cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294315" target="_blank" >RIV/00216208:11110/15:10294315 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/15:10294315 RIV/00064203:_____/15:10294315 RIV/00064165:_____/15:10294315

Result on the web

<a href="http://dx.doi.org/10.1007/s13277-014-2821-0" target="_blank" >http://dx.doi.org/10.1007/s13277-014-2821-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13277-014-2821-0" target="_blank" >10.1007/s13277-014-2821-0</a>

Result language

angličtina

Original language name

Polymorphisms of the receptor for advanced glycation end-products and glyoxalase I in patients with renal cancer

Original language description

The receptor for advanced glycation end products (RAGE) and its ligands are involved in the pathogenesis of cancer. Glyoxalase I (GLO1) is an enzyme which detoxifies advanced glycation end product (AGE) precursors. The aim of the study was to find out the relationship between four polymorphisms (single nucleotide polymorphism, SNP) of the RAGE gene (AGER) and one SNP of the GLO1 gene and clear cell renal cancer (ccRCC). All polymorphisms (rs1800625 RAGE -429T/C, rs1800624 -374T/A, rs3134940 2184A/G, rs2070600 557G/A (G82S), and GLO1 rs4746 419A/C(E111A)) were determined by PCR-RFLP in 214 patients with ccRCC. A group of 154 healthy subjects was used as control. We found significant differences in the allelic and genotype frequencies of GLO1 E111A (419A/C) SNP between patients and controls-higher frequency of the C allele in ccRCC-58.6 vs. 44.5 % in controls, OR (95 % CI) 1.77 (1.32-2.38), p = 0.0002 (corrected p = 0.001); OR (95 % CI) CC vs. AA 2.76 (1.5-4.80), p = 0.0004 (corrected p

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tumor Biology

ISSN

1010-4283

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

2121-2126

UT code for WoS article

000351884000088

EID of the result in the Scopus database

2-s2.0-84930912526