Gamma knife radiosurgery for Cushing's disease and Nelson's syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295118" target="_blank" >RIV/00216208:11110/15:10295118 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/15:00456027
Result on the web
<a href="http://dx.doi.org/10.1007/s11102-014-0584-7" target="_blank" >http://dx.doi.org/10.1007/s11102-014-0584-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11102-014-0584-7" target="_blank" >10.1007/s11102-014-0584-7</a>
Alternative languages
Result language
angličtina
Original language name
Gamma knife radiosurgery for Cushing's disease and Nelson's syndrome
Original language description
This paper presents our 18 years of experience in treating ACTH secreting adenomas (Cushing's disease and Nelson's syndrome) using the Leksell gamma knife (LGK) irradiation. Twenty-six patients with Cushing's disease were followed-up after LGK irradiation for 48-216 months (median 78 months). Seventeen patients had undergone previous surgery, in nine patients LGK irradiation was the primary therapy. Furthermore, 14 patients with Nelson's syndrome were followed-up for 30-204 months (median 144 months). LGK treatment resulted in hormonal normalization in 80.7 % of patients with Cushing's disease. Time to normalization was 6-54 months (median 30 months). The volume of the adenoma decreased in 92.3 % (in 30.7 % disappeared completely). There was no recurrence of the disease. In all 14 patients with Nelson's syndrome ACTH levels decreased (in two patients fully normalized) their ACTH levels. When checked up 5-10 years after irradiation regrowth of the adenoma was only detected in one patien
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pituitary
ISSN
1386-341X
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
376-384
UT code for WoS article
000354205000013
EID of the result in the Scopus database
2-s2.0-84930928134