Fibroblasts isolated from the malignant melanoma influence phenotype of normal human keratinocytes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295809" target="_blank" >RIV/00216208:11110/15:10295809 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10295809
Result on the web
<a href="http://dx.doi.org/10.1016/j.jab.2015.03.002" target="_blank" >http://dx.doi.org/10.1016/j.jab.2015.03.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jab.2015.03.002" target="_blank" >10.1016/j.jab.2015.03.002</a>

Result language
angličtina
Original language name
Fibroblasts isolated from the malignant melanoma influence phenotype of normal human keratinocytes
Original language description
Intercellular interactions are able to influence the biological properties of many types of tumors including malignant melanoma. Differentiation pattern of melanoma cells is significantly influenced by the melanoma-associated fibroblasts but the information about interaction of these cells with other important element of melanoma microenvironment, resp. with keratinocytes, is limited. In this, study we tested the effect of fibroblasts isolated from malignant melanoma on phenotype of normal human keratinocytes, especially on their expression of vimentin, a cytoskeletal protein weakly expressed in normal human keratinocytes. The co-culture with normal dermal fibroblasts was used for comparison. The results demonstrated the high expression of vimentin inkeratinocytes co-cultured with melanoma-associated fibroblasts compared with those co-cultured with normal dermal fibroblasts. These data suggest participation of melanoma-associated fibroblasts-keratinocyte crosstalk in formation of mela
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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