Diagnostic Importance of Selected Protein Serum Markers in the Primary Diagnostics of Prostate Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297234" target="_blank" >RIV/00216208:11110/15:10297234 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/15:10297234

Result on the web

<a href="http://dx.doi.org/10.1159/000431364" target="_blank" >http://dx.doi.org/10.1159/000431364</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000431364" target="_blank" >10.1159/000431364</a>

Result language

angličtina

Original language name

Diagnostic Importance of Selected Protein Serum Markers in the Primary Diagnostics of Prostate Cancer

Original language description

Objective: To determine a predictive model for the primary diagnosis of prostate cancer (PC) based on a multiple serum biomarker assay. Material and Methods: Between August 2011 and February 2013, a total of 387 prostate biopsies were performed. Serum or plasma concentrations of 22 biomarkers (neopterin, IGF-1, IGFBP-2, IGFBP-3, sarcosine, endoglin, TGF-beta 1, periostin, sPLA2-IIa, chromogranin A, ZAG2, clusterin, PSP94, PSP94bp, leptin, cathepsin D, hepsin, KLK11, PSMA, AMACR, CRISP3 and A1AT) were determined. Biomarker levels were correlated with the prostate biopsy results. Several statistical models for PC detection were created. Results: A total of 167 of the 373 evaluated patients (44.8%) were diagnosed with PC. None of the tested biomarkers reached statistical significance using the univariate analysis. However, the level of serum clusterin was not associated with any other tested parameter. Several basic models showed a higher positive predictive value than individual parameters. Addition of serum clusterin to the base model with prostate-specific antigen, digital rectal exam and prostate size significantly improved the area under curve value (0.723 vs. 0.716). Conclusion: Our findings suggested that multiple serum assays based on some promising markers may only have a limited practical benefit for the prediction of PC in the prostate biopsy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Urologia Internationalis

ISSN

0042-1138

e-ISSN

—

Volume of the periodical

95

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

429-435

UT code for WoS article

000366748000010

EID of the result in the Scopus database

2-s2.0-84952870263